长效微球制剂产业化研究进展

李想, 孙考祥, 李又欣

中国药学杂志 ›› 2019, Vol. 54 ›› Issue (21) : 1729-1733.

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中国药学杂志 ›› 2019, Vol. 54 ›› Issue (21) : 1729-1733. DOI: 10.11669/cpj.2019.21.001
药物制剂产业化新技术专栏

长效微球制剂产业化研究进展

  • 李想, 孙考祥, 李又欣*
作者信息 +

Progress in the Industrialization of Sustained-release Microsphere

  • LI Xiang, SUN Kao-xiang, LI You-xin*
Author information +
文章历史 +

摘要

近年来,生物降解高分子材料制备的载药微球制剂备受瞩目。因其可以进行缓控释给药,是目前高端制剂研究的热点。选择合适的高分子材料和生产技术是制备缓释微球制剂的关键因素。随着众多缓释微球制剂先后上市,微球技术逐渐发展成为一种成熟的技术工艺,也逐步呈现可控化和产业化,笔者主要介绍微球制剂的产业化生产技术和一些制备微球的新技术,以及利用微球技术上市的药物等。

Abstract

Recently, drug-loading microspheres prepared from biodegradable polymers have attracted great attentions. It is a hot topic in the research of pharmaceutical preparations because it can be used to control release of the drug. The selection of suitable polymer materials and production technology are the key factors for preparing sustained release microspheres. With the launching of many control release microspheres, the technology has been developed into a mature technology, and it has been shown to be controllable and industrialized. This paper mainly introduces the industrialized production technology of microspheres and some new technologies for preparing microspheres, as well as the drugs that have been marketed.

关键词

微球制剂 / D,L-乳酸-羟基乙酸 / 产业化

Key words

microsphere preparation / PLGA / industrialization

引用本文

导出引用
李想, 孙考祥, 李又欣. 长效微球制剂产业化研究进展[J]. 中国药学杂志, 2019, 54(21): 1729-1733 https://doi.org/10.11669/cpj.2019.21.001
LI Xiang, SUN Kao-xiang, LI You-xin. Progress in the Industrialization of Sustained-release Microsphere[J]. Chinese Pharmaceutical Journal, 2019, 54(21): 1729-1733 https://doi.org/10.11669/cpj.2019.21.001
中图分类号: R944   

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